您的位置：
首页
>
农业专利
>
详情页
Phenylpyrazole derivatives as potent inhibitors of ROCK1 and ROCK2
- 专利权人:
- Bristol-Myers Squibb Company
- 发明人:
- QUAN, Mimi L.,HU, Zilun,WANG, Cailan,GLUNZ, Peter W.
- 申请号：
- ES14710732
- 公开号：
- ES2624664T3
- 申请日:
- 2014.02.28
- 申请国别(地区):
- ES
- 年份:
- 2017
- 代理人:
- 摘要：
- A compound according to Formula (I): ** Formula ** or an enantiomer, a diastereomer, a stereoisomer, a pharmaceutically acceptable salt thereof, wherein: R1 is independently selected from H, F, Cl, Br, OH, CN, NRaRa, -O-C1-4 alkyl substituted with 0-3 Re, and C1-4 alkyl substituted with 0-3 Re； R2 is independently selected from H, - (CH2) rORb, (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNaRa - (CH2) rCN, - (CH2) rNRaC (>； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) r OC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O ) pNRaRa, - (CH2) rNRaS (O) pRc, C1-4 alkyl substituted with 0-3 Re, (CH2) r-carbocyclyl C3-6 substituted with 0-3 Re, and - (CH2) r heterocyclyl substituted with 0 -3 Re； R3 is independently selected from F, Cl, Br, CN, C1-4 alkyl substituted with 0-3 Re, - (CH2) rORb, (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb , - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNaRa- (CH2) rCN, - (CH2) rNRaC (>； = O) Rb , - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O) pNRaRa, - (CH2) rNRaS (O) pRc, (CH2) r-carbocyclyl C3-6 substituted with 0-3 Re, and - (CH2) r-heterocyclyl substituted with 0-3 Re； R4 is independently selected from H, F, Cl, Br, OH, CN, O-C 1-4 alkyl substituted with 0-3 Re and C 1-4 alkyl substituted with 0-3 Re； R5 is independently selected from H and C1-4 alkyl substituted with 0-3 Re； R6 and R7 are independently selected from H, CN, C1-4 alkyl substituted with 0-4 Re, C2-4 alkenyl substituted with 0-3 Re, - (CH2) rORb, - (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNRaRa, - (CH2) rNRaC ( >； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, -
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
