Phenylpyrazole derivatives as potent inhibitors of ROCK1 and ROCK2

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专利权人:

Bristol-Myers Squibb Company

发明人:

QUAN, Mimi L.,HU, Zilun,WANG, Cailan,GLUNZ, Peter W.

申请号：

ES14710732

公开号：

ES2624664T3

申请日:

2014.02.28

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound according to Formula (I): ** Formula ** or an enantiomer, a diastereomer, a stereoisomer, a pharmaceutically acceptable salt thereof, wherein: R1 is independently selected from H, F, Cl, Br, OH, CN, NRaRa, -O-C1-4 alkyl substituted with 0-3 Re, and C1-4 alkyl substituted with 0-3 Re； R2 is independently selected from H, - (CH2) rORb, (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNaRa - (CH2) rCN, - (CH2) rNRaC (>； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) r OC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O ) pNRaRa, - (CH2) rNRaS (O) pRc, C1-4 alkyl substituted with 0-3 Re, (CH2) r-carbocyclyl C3-6 substituted with 0-3 Re, and - (CH2) r heterocyclyl substituted with 0 -3 Re； R3 is independently selected from F, Cl, Br, CN, C1-4 alkyl substituted with 0-3 Re, - (CH2) rORb, (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb , - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNaRa- (CH2) rCN, - (CH2) rNRaC (>； = O) Rb , - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, - (CH2) rC (>； = O) ORb, - (CH2) rS (O) pNRaRa, - (CH2) rNRaS (O) pNRaRa, - (CH2) rNRaS (O) pRc, (CH2) r-carbocyclyl C3-6 substituted with 0-3 Re, and - (CH2) r-heterocyclyl substituted with 0-3 Re； R4 is independently selected from H, F, Cl, Br, OH, CN, O-C 1-4 alkyl substituted with 0-3 Re and C 1-4 alkyl substituted with 0-3 Re； R5 is independently selected from H and C1-4 alkyl substituted with 0-3 Re； R6 and R7 are independently selected from H, CN, C1-4 alkyl substituted with 0-4 Re, C2-4 alkenyl substituted with 0-3 Re, - (CH2) rORb, - (CH2) rS (O) pRc, - (CH2) rC (>； = O) Rb, - (CH2) rNRaRa, - (CH2) rC (>； = O) NRaRa, - (CH2) rC (>； = O) (CH2) rNRaRa, - (CH2) rNRaC ( >； = O) Rb, - (CH2) rNRaC (>； = O) ORb, - (CH2) rOC (>； = O) NRaRa, - (CH2) rNRaC (>； = O) NRaRa, -

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