GEUIJEN, CECILIA ANNA WILHELMINA,KLOOSTER, RINSE,DE KRUIF, CORNELIS ADRIAAN,TACKEN, PAULUS JOHANNES,THROSBY, MARK,LOGTENBERG, TON,GEUIJEN, CECILIA ANA WILHELMINA
申请号：
CA3068932
公开号：
CA3068932A1
申请日:
2018.07.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The disclosure provides means and methods for interfering with Programmed Cell Death 1 protein (PD-1) and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) mediated inhibition in a PD-1 and/or TIM-3 positive cell. A method may comprise contacting said cell with an antibody or a functional part, derivative and/or analogue thereof that comprises a variable domain that can bind to an extracellular part of PD-1 and a variable domain that can bind to an extracellular part of TIM-3, thereby inhibiting PD-1 and/or TIM-3 mediated activity in said cell. The invention also provides antibodies or variants thereof that comprises a variable domain that can bind to an extracellular part of PD-1 and a variable domain that can bind to an extracellular part of TIM-3.
