To provide agents that enhance the expression of PDPN gene or protein thereof having a cell migration promoting effect, as well as cell migration promoting agents.SOLUTION: The invention provides an agent that enhances the expression of PDPN gene or protein using a Fucus extract, as well as a cell migration promoting agent. By increasing the expression amount of PDPN gene or a protein thereof thereby elevating migration capability of fibroblasts, various symptoms due to decreased cell migration capability can be ameliorated. During the wound healing process, migration of skin fibroblasts plays an important role.SELECTED DRAWING: Figure 3【課題】細胞遊走促進効果を有するＰＤＰＮ遺伝子又はタンパク質の発現促進剤、細胞遊走促進剤の提供。【解決手段】ヒバマタ抽出物を用いた、細胞遊走促進効果を有するＰＤＰＮ遺伝子又はタンパク質の発現促進剤、細胞遊走促進剤。ＰＤＰＮ遺伝子又はそのタンパク質の発現量を高め、線維芽細胞の細胞遊走能を高めることで、細胞遊走能の低下に起因する各種症状の改善が可能となる。創傷治癒の過程では、皮膚線維芽細胞の遊走が重要な働きを有する。【選択図】図３
