SCHELLEKENS, REINOUT CORNELUS ANDREAS,FRIJLINK, HENDERIK WILLEM
申请号：
CA2617051
公开号：
CA2617051C
申请日:
2005.07.29
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to delivery systems that allow for the pulsatile releaseof a substance, such as a drug, in response to a change in pH. Morespecifically, it relates to drug administration to the GI tract, in particularto site-specific intestinal drug delivery via the oral route. Provided is a pH-controlled pulsatile release system (PPRS) comprising a core surrounded by acoating layer, wherein said core comprises an active substance and whereinsaid coating layer comprises a pH-sensitive coating material wherein aswellable agent is embedded. Said swellable agent is capable of taking up atleast 1.1 times, preferably at least 5 times, more preferably at least 10times its weight in water. Also provided is a pharmaceutical compositioncomprising a PPRS, in particular a colon-specific PPRS.
