The present invention provides compositions and methods comprising talampanel and/or perampanel for treating or preventing an addictive disease or disorder, such as alcoholism, in a subject in need thereof. AMPA receptor (AMPA-Rs) antagonists (i.e., blockers), such as perampanel and talampanel, reduce drug and alcohol seeking behaviors in mammals since activation of glutamatergic AMPA receptors promotes addictive behaviors in mammals.
