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降低鴉片樣物質持續釋放口服劑型的由醇誘導的劑量突然釋放的方法
专利权人:
ALZA CORPORATION
发明人:
GAYATRI SATHYAN,NIPUN DAVAR,JAYNE HASTEDT,LINDA PORS,GEMMA CASADEVALL
申请号:
HK07112168.4
公开号:
HK1106451B
申请日:
2007.11.08
申请国别(地区):
HK
年份:
2014
代理人:
摘要:
Oral dosage form comprises an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of the mean unit dose maximum opioid plasma concentration with alcohol coadminstration to the mean unit dose maximum opioid plasma concentration without alcohol co-adminstration is no more than 1.8:1. Independent claims are also included for: (1) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that the ratio of an individual patient unit dose maximum opioid plasma concentration with alcohol coadminstration to the individual unit dose maximum opioid plasma concentration without alcohol coadminstration is no more than 5:1; (2) oral dosage form comprising an opioid and a dosing structure that provides extended release of the opioid in the presence of aqueous alcohol with an alcohol concentration of at least 20 vol.%, such that no more than 80% of the dose is released in 2 hours in an in-vitro test performed in the presence of at least 20 vol.% alcohol. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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