MOUNTAIN VIEW PHARMACEUTICALS, INC.;DUKE UNIVERSITY
发明人:
MICHAEL S. HERSHFIELD,SUSAN J. KELLY,MARK G. P. SAIFER,MERRY R. SHERMAN,DAVID L. WILLIAMS
申请号：
BR9917760
公开号：
BR9917760B1
申请日:
1999.08.02
申请国别(地区):
BR
年份:
2014
代理人:
摘要：
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non-immunogenic and retain at least 75 % of the uricolytic activity of the unmodified enzyme.
