The present invention, according to several embodiments, comprises a compound represented by Formula I:in which the substituents BG, B, B1, R1, R100, R2, R200, A, A1, Q and Q1 are defined herein or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds of certain embodiments are useful in treating proliferative disorders such as cancer.