AS REPRESENTED BY THE SECRETERY;THE UNITED STATES OF AMERICA; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
MCGAVERN, DORIAN B.,ROTH, THEODORE
申请号：
EP13748662
公开号：
EP2814474A4
申请日:
2013.02.05
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Disclosed is a method of treating or preventing a disease or disorder of the central nervous system (CNS) in a patient comprising administering transcranially, for example, directly to the skull, an effective amount of an anti-inflammatory agent to the patient. Examples of the anti-inflammatory agent include glutathione and inhibitors of purinergic receptors such as P2X4, P2X7, P2Y6, and P2Y12 receptors. Examples of disease or disorder of the CNS include brain injury, particularly traumatic brain injury, inflammation, infection, degeneration of brain cells, stroke, brain edema, tumor, Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Also disclosed is a kit comprising at least one anti-inflammatory agent and printed materials containing instructions for transcranially administering the anti-inflammatory agent to the patient having a disease or disorder of the CNS, disorder of the CNS.
