This creation is a kind of safe needle holder group and its replaceable type pedestal. Aforementioned replaceable type pedestal includes a pedestal, an anti-needle bundle protector and a press section. Pedestal system is further provided with a perforation to a needle holder outside movable connection, pedestal, and perforation system what connects the interconnecting piece of external needle set. One end system that anti-needle pricks protector connect with pedestal, and anti-needle pricks protector can cover the syringe needle of needle set with respect to what pedestal activity, and under what lid molding state. Press section system sets one of what pedestal portion, and to separate pedestal and needle holder under what pressing mode.本創作係一種安全持針器組及其可置換式底座。前述之可置換式底座包含一座體、一防針扎護具以及一按壓部。座體係用以活動式連接外部一持針器,其座體更設有一貫孔,該貫孔係用於連接外部針具之連接部。防針扎護具之一端係與座體連接,其防針扎護具可相對於座體活動,並於蓋合模態下覆蓋針具之針頭。按壓部係設於座體之一部,並於按壓模態下以分離座體以及持針器。