FUNG, Michael, S., C.,SUN, Cecily,LU, Meisheng,SUN, William
申请号：
MX2015001193
公开号：
MX342385B
申请日:
2002.08.17
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The invention relats to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitors molecule is the monoclonal antibody designated MAb137-26 which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated bx excessive or uncontrolled production of C5a. The inhibitors moleculesl are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.La presente invención se refiere a un ácido nucléico aislado que encoda un anticuerpo o un fragmento de unión a antígeno del mismo, en donde el anticuerpo o el fragmento de unión a antígeno del mismo, se une a C5 humano y C5a, y en donde el anticuerpo es una forma quimérica, desinmunizada o humanizada del anticuerpo monoclonal 137-26 producido a partir del hibridoma depositado en la ATCC y designado Pta-3650.
