Methods and devices are provided for vessel preparation to facilitate adjunctive therapies including the delivery of therapeutic drugs. An ultrasound catheter is provided, which has an ultrasound transmission member or wire with an affixed tip on the distal end, and an attached sonic connector on the proximal end extending through the catheter shaft which has a distal end coaxially positioned inside the tip and affixed to the tip. The ultrasound device propagates ultrasound energy while undergoing irrigation.
