A composition comprising a mixture of chlorohexidine, a surfactant, and a cationic quaternary ammonium compound is suitable for use as an antiseptic and is surprisingly effective against difficult-to-kill organisms such as Mycobacterium tuberculosis and against Methicillin-resistant Staphylococcus aureus (MRSA) while still being suitable for topical application. The composition may include a chelating agent.
