WAVE LIFE SCIENCES LTD.;WAVE LIFE SCIENCES PTE. LTD.
发明人:
BUTLER, DAVID,IWAMOTO, NAOKI,MEENA, MEENA,SVRZIKAPA, NENAD,VERDINE, GREGORY L.,ZLATEV, IVAN
申请号：
CL2015000092
公开号：
CL2015000092A1
申请日:
2015.01.13
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.<；p>；una composició；n de oligonucleó；tido quiralmente controlado que comprende una pluralidad de oligonucleó；tidos de al menos un tipo en donde cada tipo es definido por: 1) secuencia base； 2) patró；n de enlaces de armazó；n； 3) patró；n de centros quirales de armazó；n； y 4) patró；n porciones-x de armazó；n (-X-L-R1).<；/p>；
