Lino DA SILVA FERREIRA,Miguel Maria DA FONSECA MIRANDA FERREIRA LINO
申请号：
US15768757
公开号：
US20180303937A1
申请日:
2016.10.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure relates to the modulation of cell activity by sequential release of several biomolecule from a given nanocarrier using a given wavelength. The present disclosure describes a composition for controlled release of biomolecules comprising: a gold nanoparticle at least two different biomolecules at least two different oligonucleotides having different melting points, binding said biomolecules to the surface of the gold nanoparticle wherein the binding is obtainable via hybridization of complementary oligonucleotides wherein each of the oligonucleotides is a photo-active such that the respective biomolecule is releasable by photo-activation. The composition of the present disclosure may be use in medicine, namely in the treatment of cancer, aging diseases, and accelerated aging syndromes, infectious diseases such as AIDS, epigenetic diseases such as polycystic ovary syndrome, or cardiac diseases, such as cardiac regeneration.
