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Sulfonamide compound
专利权人:
MITSUBISHI TANABE PHARMA CORPORATION
发明人:
Taku Kato,Toshiaki Sakamoto,Akira Kubo,Daisuke Sawamoto
申请号:
US14428267
公开号:
US09487488B2
申请日:
2013.09.13
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides novel sulfonamide compounds having TRPM8 antagonistic activity which are useful as medicaments. Specifically, the present invention provides a sulfonamide compound of the formula (I):wherein Ring A is the following formula (i), (ii), or (ix):R4 is optionally substituted alkyl,X1 and X2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, orR4 and X2 combine with each other at their terminals together with the adjacent benzene to form indazolinonyl or benzoisoxazolonyl, andthe other symbols are the same as described in the specification,or a pharmaceutically acceptable salt thereof.
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