LEE CHRISTOPHER A,REDMON MARTIN P,KANE JOHN C,REED DAVID P,CHEN JIAN-XIE,BARNES NEIL R
申请号：
NZ62808710
公开号：
NZ628087A
申请日:
2010.12.21
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure relates to a form 1 and form 2 polymorph of (-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione. The present disclosure also relates to (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4- (1H-indol-3-yl) pyrrolidine-2, 5-dione compounds having a chiral purity greater than 99%, and methods of preparation of these compounds. Also disclosed are pharmaceutical compositions comprising these (-)-trans-3-(5,6-dihydro-4H-pyrrolo [3,2,1-ij] quinolin-1-yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione compounds, which are suitable for treating a cell proliferative disorder, such as a cancer.
