The present invention relates to a pharmaceutical composition for treating urinary incontinence and/or enuresis, which comprises at least 0.5 - 20 wt% of a mixture of flavonoids, 2 - 20 wt% of condensed tannins or proantocyanidins and 0.3 - 60 wt% of gamma aminobutyric acid (GABA), with respect to the total composition. Said composition additionally comprises at least 50% of a Humulus lupulus extract. The present invention also relates to the use of said composition for preparing a medicine for treating incontinence and/or enuresis, in particular enuresis in children, as well as in adults or the elderly who have urine leaks such as incontinence due to stress or urgency.