A composition containing a newly identified bacteriocin produced by a Lactobacillus plantarum strain, isolated from natural corn mash used in commercial fermentation process for production of ethanol. The bacteriocin composition is effective in broad range killing against the vast majority of the lactic acid bacteria (LAB) isolates in ethanol fermentation mash, which include multiple species of Lactobacillus, Lactococcus, Weissella, Leuconostoc, Pediococcus, Enterococcus, and Streptococcus as well as killing activity against non-LAB isolates, such as strains of Staphylococcus, Enterobacter, Bacillus, and Clostridium. The bacteriocin is also combined with broad range bacteriophage to provide synergistic effectiveness again unwanted bacteria in industrial biofuel fermentation process and in human and animal bacterial infections.
