Mixing systems and methods include a mixing device comprising a primary tubehaving a proximal end, a distal end,an outer surface and an inner lumen and at least one secondary tube having aproximal end, a distal end, an outer surface and an innerlumen. The at least one secondary tube is substantially parallel to theprimary tube. The distal end of the at least one secondarytube is fluidly connected to the primary tube at a junction located on theprimary tube close to the distal end of the primary tube.