COMBINATION THERAPY WITH TARGETED 4-1BB (CD137) AGONISTS

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专利权人:

Hoffmann-La Roche Inc.

发明人:

Marina BACAC,Christina CLAUS,Claudia FERRARA KOLLER,Christian KLEIN,Sabine LANG,Viktor LEVITSKI,Pablo UMAÑA

申请号：

US16825773

公开号：

US20200325225A1

申请日:

2020.03.20

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention relates to combination therapies employing tumor targeted anti-CD3 bispecific antibodies and/or agents blocking PD-L1/PD-1 interaction in combination with 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies.

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