Synthesizing strontium ranelate compounds (I) and their hydrates, comprises: reacting 3-cyano thiophene compound (II) with soda or potash, in water or mixture of water and organic solvent at 0-100[deg] C, to give a salt of 5-(bis-carboxymethyl-amino)-3-carboxymethyl-4-cyano-thiophene-2-carboxylic acid (III)； and reacting strontium chloride with mixture of water and organic solvent at 0-100[deg] C to give (I), after the isolation. Process for synthesizing strontium ranelate compounds of formula (I) and its hydrates, comprises: reacting 3-cyano thiophene compound of formula (II) with soda or potash, in water or mixture of water and organic solvent at 0-100[deg] C, to give a salt of 5-(bis-carboxymethyl-amino)-3-carboxymethyl-4-cyano-thiophene-2-carboxylic acid of formula (III)； and reacting strontium chloride with mixture of water and organic solvent at 0-100[deg] C to give (I), after the isolation. R, R1 : 1-6C alkyl, preferably CH 3； and A : Na or K. An independent claim is included for a potassium salt of 5-(bis-carboxymethyl-amino)-3-carboxymethyl-4-cyano-thiophene-2-carboxylic acid of formula (IIIb). [Image] [Image] [Image] ACTIVITY : Osteopathic. MECHANISM OF ACTION : None given.
