#$%^&*AU2018202271B220191212.pdf#####Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex-vivo. Also provided herein are screening assays for an agent for inducing apoptosis using cultured seborrheic keratosis cells, and methods for treating seborrheic keratosis in a subject. Methods of treating seborrheic keratosis in a subject by administering a composition that inhibits the Akt signalling pathway by topical or systemic administration of a small molecule, peptide or RNAi agent is also provided herein. The inhibitors are Akt-1 or Akt-2 inhibitors or are pan-Akt inhibitors.
