DUKE UNIVERSITY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
BIGNER, DARELL,KUAN, CHIEN-TSUN,SAMPSON, JOHN,CHOI, BRYAN,PASTAN, IRA H.,GEDEON, PATRICK C.
申请号：
EP13800038
公开号：
EP2861619A4
申请日:
2013.06.07
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging molecules are highly cytotoxic and antigen-specific. These may be used as therapeutic agents.
