Venskus, Dite,Kalvins, Ivars,Pjanova, Dace,Petrovska, Ramona,Auzins, Jurgis
申请号：
AU2014292114
公开号：
AU2014292114B2
申请日:
2014.07.16
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus, isolated by a known method from human feces and identified by genome sequence,the modification is performed initially conducting the virus adaptation in cancer cells, attenuated by anti-cancer agent dacarbazine, further passaging the modified virus in human embryonal fibroblast culture, followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture, that was treated by ribavirin, isolation and purification by known method. The modified virus is suitable for treating various tumours.
