The present invention relates to the use of Antibacterials in the treatment of epithelial related diseases. In this paper, the method of inactivating and / or decontaminating bacteria on the surface is revealed. The invention also discloses a method for treating epithelial conditions (such as acne vulgaris) caused or aggravated by bacteria in an individual in need. The invention further discloses compounds and compositions of the invention that exhibit anti-bacterial and / or anti-inflammatory effects.本發明涉及抗細菌劑用於治療上皮相關病况的用途。本文揭示將表面上的細菌滅活和/或去殖化(decolonizing)的方法。本發明還揭示在有需要的個體中治療由細菌引起或加重的上皮病况(例如尋常痤瘡)的方法。本發明另外揭示展現抗細菌和/或消炎效應的本發明化合物和組合物。