Methods and pharmaceutical compositions for reducing number of gout flares experienced by a patient are disclosed. The methods can comprise administering to a patient with hyperuricemia an effective amount of a xanthine oxidase inhibitor in a modified release dosage form once daily or in an immediate release dosage form two or more times daily to prevent at least one gout flare or reduce the number of gout flares experienced by the patient.揭示用於降低病患經歷痛風發作次數的方法與藥學組成物。該方法包含將有效量之黃嘌呤氧化酶抑制劑以修飾釋放劑型每日一次地或以立即釋放劑型每日二或多次地投予高尿酸血症病患以預防該病患經歷至少一次痛風發作或降低痛風發作次數。
