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DÉRIVÉS DURÉE DE TETRAHYDROQUINOXALINE, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
专利权人:
SANOFI
发明人:
NAMANE, CLAUDIE,NICOLAI, ERIC,PACQUET, FRANÇOIS,PASCAL, CÉCILE,VENIER, OLIVIER
申请号:
EP10752090.0
公开号:
EP2459549B1
申请日:
2010.07.23
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The invention relates to compounds of formula (I), where: A is a bond, an oxygen, or an –O-CH2- group Ar1 is a phenyl or heteroaryl group Ar2 is a phenyl, heteroaryl, or heterocycloalkyl group R1a,b,c and R2a,b,c are hydrogen or halogen, or an alkyl, cycloalkyl, or –alkyl-cycloalkyl group optionally substituted by one or more halogen atoms, or a -OR5 (hydroxy or alkoxy), hydroxy-alkyl, alkoxy-alkyl, alkoxy-alkoxy, halogenoalkyl, -O-halogenoalkyl, oxo, -CO-alkyl, -CO-alkyl-NR6R7, -CO-halogenoalkyl, -COOR5, alkyl-COOR5, -O-alkyl-COOR5, -SO2-alkyl, -SO2-cycloalkyl, -SO2-alkyl-cycloalkyl, -SO2-alkyl-OR5, -SO2-alkyl-COOR5, -SO2-alkyl-NR6R7, -SO2-halogenoalkyl, alkyl-SO2-alkyl, -SO2-NR6R7, -SO2-alkyl-O-alkyl-OR5, -CONR6R7, -alkyl-CONR6R7, or –O-alkyl-NR6R7 group, or further R1a, R1b, and R1c are bonded to R2a, R2b, R2c, respectively, and to the carbon atom having same, and are –O-alkyl-O- R3 is a hydrogen atom or an alkyl group R4 is a hydrogen or halogen atom or a cyano, -OR5, hydroxyalkyl, -COOR5, -NR6R7, –CONR6R7, -SO2-alkyl, SO2-NR6R7, -NR6-COOR5, -NR6-COR5, or -CO-NR6-alkyl-OR5 group R5, R6, and R7 are a hydrogen, or an alkyl or alkyl-phenyl group and R8 is an alkyl, alkyl-Si(alkyl)3, -SO2-alkyl-Si(alkyl)3, phenyl, alkoxy-imino group, or alkyl-cycloalkyl group optionally substituted by one or more halogen atoms or one or more hydroxyl or hydroxyl-alkyl groups or R8 and R9, together with the carbon atoms to which they are bonded, form a cycloalkyl group optionally substituted by one or more halogen atoms or one or more carboxy groups and R9 is a hydrogen atom or an alkyl group with the proviso that, when R8 is an alkyl group, it is bonded onto the Ar2 silicon atom. The invention also relates to a method for preparing same and to the therapeutic use thereof.Linvention concerne des composés répondant à la formule (I), dans laquelle A représente une liaison, un oxygène ou un groupe -O-CH2- Ar1 représente un groupe phényle ou hétéroaryle Ar2 représente un groupe phényle,
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