ABSTRACT - 594669 Disclosed herein is a pharmaceutical composition for oral administration in capsule form comprising suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient in powder form, wherein about 100 mg of the active ingredient has an in vitro dissolution profile with a similarity factor (f2) of at least 56 to 100 compared to the reference dissolution profile of 52.7% dissolved at 10 minutes, 61.7% dissolved at 15 minutes, 67.7% dissolved at 20 minutes, 75.5% dissolved at 30 minutes, 82.6% dissolved at 45 minutes, and 87.0% dissolved at 60 minutes in vitro, wherein the total % volume of active ingredient with particle size less than about 105 microns is about 45-85% and the total % volume of active ingredient with particle size more than about 105 microns is about 55-15%, and optionally a pharmaceutically acceptable excipient that is a powder blend.
