John Robert DUTCHER,Terry J. BEVERIDGE,Anton KORENEVSKI,Oleg STUKALOV,Erzsebet PAPP-SZABO
申请号：
US15816893
公开号：
US20180135079A1
申请日:
2017.11.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Polysaccharide nanoparticles that are particularly useful in for example drug and agent delivery, tissue-specific targeting, for medical imaging and diagnosis, as well as modifiers of physico-chemical properties. The nanoparticles can be highly-branched glucose homopolymers and can be characterized by a uniform spherical shape. They are monodisperse, hydrophilic and produce low solution viscosities. The nanoparticles are non-toxic, biocompatible and biodegradable. Also, the process of isolation of said polysaccharide nanoparticles from various organisms including, but not limited to, microorganisms such as bacteria and yeasts. Also provided are methods for chemical conjugation of the polysaccharide nanoparticles with various agents. Also provided are examples of use of the polysaccharide nanoparticles and their derivatives as drug delivery systems and fluorescent diagnostics.
