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ХЕЛАТНЫЕ АМФИФИЛЬНЫЕ ПОЛИМЕРЫ
专利权人:
КОНИНКЛЕЙКЕ ФИЛИПС ЭЛЕКТРОНИКС Н.В. (NL)
发明人:
ГРУЭЛЛ Хольгер (NL),ДЕ ВРИС Анке (NL),ЛАНГЕРЕЙС Сандер (NL),ЛУБ Йохан (NL),АУССЕМС-КУСТЕРС Эрика М.Г. (NL)
申请号:
RU2011113841/15
公开号:
RU2011113841A
申请日:
2009.09.08
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: group of inventions relates to a chelate amphiphilic polymer as a carrier, a particle as a carrier containing a self-assembling structure of a chelating amphiphilic polymer (polymersome), contrast agents for CEST MRT, SPECT, PET or Spectral CT, containing said particle, and a method of producing the particle. The chelate amphiphilic polymer is capable of aggregation and contains a hydrophilic block (MA), having a chelating moiety (X) as a terminal group and a hydrophobic block (MB), wherein the polymer has the formula X-[MA]n - [MB]m, (i), where n and m are integers ranging from 3 to 1000000, which represent the number of monomer links forming the corresponding blocks. The hydrophilic block is selected from polyethylene oxide, polymethacrylic acid, polyacrylamide derivatives, polyvinyl alcohol or polyhydroxyethylmethacrylate, hydrophilic polypeptides and sugar derivatives. The hydrophobic block is selected from polybutadiene, polyisoprene and polyethylethylene. The chelating moiety is selected from a group comprising polyphosphates, amino carboxylic acids, 1,3-diketones, hydroxy carboxylic acids, polyamines, amino alcohols, aromatic heterocyclic bases, phenols, amino phenols, oximes, peptides containing proximal chelate functional groups, Schiff bases, tetrapyrroles, sulphur compounds, synthetic macrocyclic compounds, phosphonic acid or a combination of two or more of said compounds.EFFECT: invention provides chelate amphiphilic polymers which are capable of self-assembling and are suitable for use in vulcanisation methods.14 cl, 7 dwg, 4 exГруппа изобретений относится к хелатному амфифильному полимеру в качестве носителя, частице в качестве носителя, содержащей способную к самоагрегации структуру хелатообразующего амфифильного полимера (полимерсому), контрастным средствам для CEST МРТ, ОФЭКТ или ПЭТ или спектральной КТ, содержащим указанную выше частицу, а также способу получения частицы. Хелатный амфифильный полимер способен к агрегации
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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