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Triazole derivative or salt thereof
专利权人:
Astellas Pharma Inc.
发明人:
Kawano, Noriyuki,Koike, Takanori,Munakata, Ryosuke,Fukudome, Hiroki,Yoshimura, Seiji,Sasuga, Daisuke,Mihara, Kayoko,Shiraishi, Nobuyuki,Hoshii, Hiroaki,Watanabe, Hideyuki,Kawano, Tomoaki
申请号:
AU2009266756
公开号:
AU2009266756B2
申请日:
2009.07.02
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
Disclosed is a compound which can be used for the prevention or treatment of a disease associated with 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1), particularly diabetes, insulin resistance, dementia, schizophrenia or depression. Specifically disclosed is a triazole derivative which is characterized by having a (di)alkylmethy or cycloalkyl substituted by a group -O-(an aryl or heterocyclic group which may be substituted or a lower alkylene-cycloalkyl which may be substituted) at one position selected from position-3 and positin-5 in the triazole ring and an aryl or heterocyclic group which may be substituted or a cycloalkyl which may be substituted at the other position in the triazole ring, or a pharmaceutically acceptable salt thereof.  It is found that the triazole derivative or the pharmaceutically acceptable salt thereof has a potent inhibitory activity on 11β-HSD1.  Therefore, the triazole derivative can be used for the prevention or treatment of diabetes, insulin resistance, dementia, schizophrenia or depression.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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