ГРАНТ Маршалл (US),МЕНКИН Пол (US),СТОУЭЛЛ Грейсон У. (US)
申请号：
RU2014101305/15
公开号：
RU2014101305A
申请日:
2012.06.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A composition comprising a plurality of microparticles of diketopiperazine and a drug or active substance； where each microparticle of diketopiperazine contains many structural domains； moreover, these microparticles of diketopiperazine have a weight average particle size of from about 33,000 to about 216,000 voxels, measured by x-ray tomography for particles having a geometric diameter from about 0.5 μm to about 4 μm. 2. The composition of claim 1, wherein the microparticles of diketopiperazine comprise from about 140 to about 170 structural domains. The composition according to claim 1 or 2, where the microparticles of diketopiperazine contain structural domains having a number average size in the range from about 250 voxels to about 1400 voxels. The composition of claim 1, wherein the microparticles of diketopiperazine comprise structural domains having a midoxel size in the range of about 500 voxels to about 2000 voxels. The composition according to claim 1, where each microparticle of diketopiperazine has a specific surface area of more than 35 m / g. The composition according to claim 1, where each microparticle of diketopiperazine has a specific surface area of more than 70 m / g. The composition of claim 1, wherein the plurality of structural domains has an average size of from about 300 nm to about 450 nm, as measured using an inertia radius. The composition of claim 1, wherein said drug or active substance is a small organic molecule, a peptide or protein, a nucleic acid molecule, or a combination thereof. The composition of claim 8, where the specified ne1. Композиция, содержащая множество микрочастиц дикетопиперазина и лекарственное средство или активное вещество； где каждая микрочастица дикетопиперазина содержит множество структурных доменов； причем указанные микрочастицы дикетопиперазина имеют средневзвешенный по массе размер частиц, составляющий приблизительно от 33000 до приблизительно 216000 вокселов, измеренный методом рентгеновской томографии д
