Heyue ZHOU,Barbara A. SWANSON,Edwige GROS,Allyson TERRY
申请号：
MX2017011443
公开号：
MX2017011443A
申请日:
2016.03.07
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
There is disclosed compositions and methods relating to or derived from anti-JAGl antibodies. More specifically, there is disclosed fully human antibodies that bind JAGl, JAGl -binding fragments and derivatives of such antibodies, and JAGl -binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having JAGl related disorders or conditions. There is also disclosed a method for treating JAGl -expressing tumors, including hepatocellular carcinomas and squamous carcinomas, and non-oncology diseases selected from the group consisting of rheumatoid arthritis, experimental lung injury, atherosclerosis, chronic liver disease induced by hepatitis C virus, ischemic myocardial injury and heart failure.Se describen composiciones y métodos que se refieren a o derivan de anticuerpos anti-JAG1. De manera más específica, se describen anticuerpos completamente humanos que se unen a JAG1, fragmentos de unión a JAG1 y derivados de tales anticuerpos y polipéptidos de unión a JAG1 que comprenden tales fragmentos. Aún más, se describen ácidos nucleicos que codifican tales anticuerpos, fragmentos de anticuerpos y derivados y polipéptidos, células que comprenden tales polinucleótidos, métodos para hacer tales anticuerpos, fragmentos de anticuerpos y derivados y polipéptidos y métodos para usar tales anticuerpos, fragmentos de anticuerpos y derivados y polipéptidos, incluyendo métodos para tratar o diagnosticar sujetos que tienen trastornos o condiciones relacionados con JAG1. También se describe un método para tratar tumores que expresan JAG1, incluyendo carcinomas hepatocelulares y carcinomas escamosos y e
