The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (σ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.本發明涉及具有針對西格瑪(σ)受體的藥理學活性的經取代的啉衍生物,涉及此類化合物的製備方法,涉及包含它們的藥物組成物,並且涉及它們在治療中的用途,特別是用於治療疼痛。