An accommodating intraocular lens (40) is provided that having optical parameters that are altered in-situ using forces applied by the ciliary muscles, in which a lens body carries an actuator (42) separating two fluid-filled chambers (57,62) having either the same index of diffraction or different indices of refraction, actuation of the actuator changing the relative volumes of fluid (59,65) within an optic element of the lens and altering the optical power of the lens.