A compound of formula (I) or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M 1 , M 2 , L 1 , L 2 , W 1 , W 2 , X 1 , X 2 , Y 1 , Y 2 , A, R 5 and R 5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.