BENZ, CHRISTOPHER C.,PAPAHADJOPOULOS, DEMETROIS,PARK, JOHN W.,HONG, KEELUNG,KIRPOTIN, DMITRI
申请号：
CA2249352
公开号：
CA2249352C
申请日:
1997.04.01
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention provides for immunoliposomes that optimizesinternalization of a drug into target cells bearing a characteristic cellsurface marker. The immunoliposomes comprise a Fab domain of an antibody thatspecifically binds the characteristic marker, an amphipathic vesicle-forminglipid, and a polyethylene glycol derivatized lipid. The invention alsoprovides for growth-inhibiting immunoliposomes that lack growth-inhibitingtherapeutic agents and yet are capable of inhibiting the growth andproliferation of target cells.
