The provision of a substance that binds to FZD10 specifically and with high affinity, and a pharmaceutical comprising the same. A peptide having 11 to 50 amino acids having an amino acid sequence represented by at least the following formula (1). (Wherein X1 represents Lue or Met, X2 represents Pro, Val, Ile, Met or Leu, X3 represents Ser, Ala, Thr, Gly, Asn, Asp, Glu, Arg or Lys, and X4 represents Le5, Met, Phe or Trp, X5 represents His, Tyr, Phe, Lys, Arg, Ala, Leu or Met, X6 represents Met, Leu, Ile, Val, Ala, Phe, Tyr, Trp or Cys X7 represents Tyr or Phe.)ＦＺＤ１０に特異的かつ高親和性で結合する物質及びそれを含む医薬の提供。少なくとも下記式（１）で表されるアミノ酸配列を有するアミノ酸数１１～５０のペプチド。（式中、Ｘ１はＬｕｅ又はＭｅｔを示し、Ｘ２はＰｒｏ、Ｖａｌ、Ｉｌｅ、Ｍｅｔ又はＬｅｕを示し、Ｘ３はＳｅｒ、Ａｌａ、Ｔｈｒ、Ｇｌｙ、Ａｓｎ、Ａｓｐ、Ｇｌｕ、Ａｒｇ又はＬｙｓを示し、Ｘ４はＬｅｕ、Ｍｅｔ、Ｐｈｅ又はＴｒｐを示し、Ｘ５はＨｉｓ、Ｔｙｒ、Ｐｈｅ、Ｌｙｓ、Ａｒｇ、Ａｌａ、Ｌｅｕ又はＭｅｔを示し、Ｘ６はＭｅｔ、Ｌｅｕ、Ｉｌｅ、Ｖａｌ、Ａｌａ、Ｐｈｅ、Ｔｙｒ、Ｔｒｐ又はＣｙｓを示し、Ｘ７はＴｙｒ又はＰｈｅを示す。）
