Disclosed herein are induced hepatocytes from a trophoblast stem cell, methods for inducing the cells, and compositions thereof. Also disclosed herein are methods of treating a disease or disorder (e.g., liver-associated) by utilizing an induced hepatocyte disclosed herein.本發明揭示來自於一滋養層幹細胞的經誘導的肝細胞、用於誘導該等細胞的方法,以及它們的組成物。本發明亦揭示藉由利用本發明所揭示的一經誘導的肝細胞來治療一疾病或障礙(例如,肝-關聯性)的方法。