KUAN-JU CHEN,MANIJEH NAZARI GOLDBERG,MARIA JOSE ALONSO
申请号：
BR112015020851
公开号：
BR112015020851A2
申请日:
2014.02.21
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
A delivery device for topical and systemic delivery of agents to targeted oral locations, such as mouth cancer cells, has been developed. The formulation includes a mucoadhesive polymeric matrix such as chitosan, which contains one or more therapeutic and/or diagnostic agents, taste masking agents, permeation enhancers, the therapeutic or diagnostic agent to be delivered, and a hydrophilic polymeric coating such as polyethyleneglycol (&ldquo；PEG&rdquo；). In the preferred embodiment, the matrix is formulated with one side having the PEG-mucoadhesive polymer exposed for topical placement onto epithelial or cancer cells in the mouth or other mucosal area and the side(s) facing the inside of the oral cavity being covered with a biocompatible, inert membrane that is impermeable to the therapeutic and/or diagnostic agent(s) to be delivered.
