Compositions and methods for treating Alzheimers disease

• 收藏
• 分享

专利权人:

Cangene U.S.; Incorporated

发明人:

Cashman, Neil R.,McClarty, Grant

申请号：

AU2012335014

公开号：

AU2012335014A1

申请日:

2012.11.12

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

The present disclosure provides for a hyperimmune preparation comprising human polyclonal antibodies or fragments thereof specific to a cyclic peptide having an amino acid sequence comprising SNK. The cyclic peptide may comprise an amino acid sequence GSNK (SEQ ID NO: 1 ), SNKG(SEQ ID NO: 2), GSNKG (SEQ ID N0:3), CSNKG (SEQ ID NO: 4), CGSNKGC (SEQ ID NO: 5), CGSNKGG (SEQ ID NO: 6), or CCGSNKGC (SEQ ID NO: 7). The antibodies in the hyperimmune preparation may have a titer ranging from about 200 to about 400 mean fluorescence intensity (MFI). In one embodiment, greater than about 80% of the antibodies in the hyperimmune preparation are IgG. The fragments of the antibodies are Fab, F(ab)2, scFv, disulfide linked Fv, or mixtures thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/