The present disclosure provides antibody sequences found in antibodies thatbind to human CD38. In particular, thepresent disclosure provides sequences of anti-human CD38 antibodies.Antibodies and antigen-binding portions thereof including suchsequences present features compatible with pharmaceutical manufacturing anddevelopment can be provided as fully human antibodies(e.g., fully human monoclonal antibodies or antigen-binding fragments) thatcan be useful for medical methods and compositions, inparticular for treating cancer.