KHANDAJINSKAYA, ANASTASIYA, LVOVNA,YASKO, MAXIM VLADIMIROVICH,SHIROKOVA, ELENA ANATOLIEVNA,SHIPITSYN, ALEXANDER V.,POKROVSKY, ANDREY GEORGIEVICH
申请号：
EP05763842
公开号：
EP1829885A4
申请日:
2005.05.06
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3-azido-3-deoxythymidine phosphonates with the following general formulawhere R = alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, alkoxy- and acyloxy- groups as well as substituted aminocarbonyl groups.The compounds can be used as antiviral agents as they have low toxicity and can effectively inhibit replication of type 1 immunodeficiency virus in MT-4 cell culture and generate AZT in mammalians ensuring a gradual increase of its concentration in the blood.
