Present disclose provides method treat slight brain injury and other nerve subject in need methods, including to a effective amount of compound of snibject include ghrelin or Leptin variant. The present invention provides methods to treat slight brain injury or cerebral concussion patients, method described therein includes giving to need its object with the slight brain injury or a effective amount of ghrelin variants of concussion or composition, it includes ghrelin deformations to treat the mild brain injury or oscillation.