Ayesa, Susana,Belfrage, Anna Karin,Classon, Bjorn,Grabowska, Urszula,Hewitt, Ellen,Ivanov, Vladimir,Jonsson, Daniel,Kahnberg, Pia,Lind, Peter,Nilsson, Magnus,Oden, Lourdes,Pelcman, Mikael,Wahling, Hor
申请号：
AU2009329066
公开号：
AU2009329066B2
申请日:
2009.12.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compounds of the formula I wherein R is H； and R is C-C alkyl, Carbocyclyl or Het； or R and R together define a saturated cyclic amine with 3-6 ring atoms； R and R are H, halo, C-Calkyl, C-Chaloalkyl, C-Calkoxy； or R and R together with the carbon atom to which they are attached form a C-Ccycloalkyl； R is a branched C-Calkyl chain, C-Chaloalkyl or C-Ccycloalkylmethyl, R is Het, Carbocyclyl, optionally substituted as defined in the specification and pharmaceutically acceptable salts, hydrates and N-oxides thereof； are inhibitors of cathepsin S and have utility in the treatment of psoriasis, autoimmune disorders and other disorders such as asthma, arteriosclerosis, COPD and chronic pain
