PROBLEM TO BE SOLVED: To provide a method and composition useful for the diagnosis and treatment of angiogenic disorders, including cancer.SOLUTION: According to the present invention, a method is provided for identifying a patient who may benefit from treatment with an anti-cancer therapy other than or in addition to a VEGF-A antagonist. The method comprising determining an expression level of at least one gene in a sample obtained from the patient. Here, an increased expression level of the at least one gene in the sample as compared to a reference sample indicates that the patient may benefit from treatment with the anti-cancer therapy.SELECTED DRAWING: Figure 2【課題】癌を含む血管形成性疾患の診断及び治療に有用な方法及び組成物をここに開示する。【解決手段】ＶＥＧＦ－Ａアンタゴニスト以外の抗癌療法、または、ＶＥＧＦ－Ａアンタゴニストと抗癌療法による治療から利益を得うる患者を識別する方法であって、患者から得た試料において特定の遺伝子の発現レベルを決定することを含み、このとき参照試料と比較して該試料における少なくとも一の遺伝子の発現レベルの増加が、該患者が該抗癌療法による治療から利益を得うることを示す方法。【選択図】図２
