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UNIT STRUCTURE-TYPE PHARMACEUTICAL COMPOSITION FOR NUCLEIC ACID DELIVERY
专利权人:
NanoCarrier Co., Ltd.;THE UNIVERSITY OF TOKYO
发明人:
Kazunori KATAOKA,Kanjiro MIYATA,Nobuhiro NISHIYAMA,Kensuke OSADA,Sumiyo WATANABE,Shigeto FUKUSHIMA,Hiroyuki CHAYA,Hiroyasu TAKEMOTO,Yasuki KATO
申请号:
US15879821
公开号:
US20180153920A1
申请日:
2018.01.25
申请国别(地区):
US
年份:
2018
代理人:
摘要:
A unit structure consists of a single nucleic acid having a length of 10 to 30 bases, and a single block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment. In this unit structure: (i) a difference between a total of positive charges derived from cationic groups of the cationic polyamino acid segment and a total of negative charges derived from the nucleic acid in the unit structure falls within a range of ±10% of the total of the negative charges derived from the nucleic acid, (ii) the hydrophilic polymer chain segment comprises polyethylene glycol, (iii) the polyethylene glycol has a radius of inertia (Rg) equal to or longer than the length of the nucleic acid, and (iv) the cationic polyamino acid segment is bound to the nucleic acid via electrostatic bonds.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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