A method of creating a diagnostic evaluation for usual interstitial pneumonia is provided, including obtaining a first plurality of series of HRCT lung slices indicating the presence of UIP, obtaining an identification of UIP and non-UIP voxels, extracting textural and localization features from the UIP and non-UIP voxels, selecting features that are more accurate in differentiating UIP voxels from non-UIP voxels than other features are, eliminating features highly correlated with a more accurate feature, and constructing a predictive model by performing a second classifier to provide a probability that a voxel signifies the presence of UIP. Also provided is a method of identifying UIP in a subjects lung by applying a diagnostic evaluation for UIP that was created with the foregoing method.
