Shanghai Hansoh Biomedical Co., Ltd.;Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
发明人:
申请号：
EP16785828.1
公开号：
EP3290429A1
申请日:
2016.04.13
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention relates to a cholic acid derivative, and a preparation method and a medical use thereof. In particular, the present invention relates to a cholic acid derivative with the structure of formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof. The series of compounds can be used to treat FXR mediated diseases, comprising cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hyperlipidemia and chronic hepatitis diseases, chronic liver diseases, gastrointestinal diseases, nephrosis, heart vascular diseases, metabolic diseases, cancer (for example colorectal cancer) or neurological signs, such as strokes and other diseases, with a wide range of medical applications, and are expected to develop into a new generation of FXR agonist.
